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Breast cancers that initially respond to hormone therapies, like tamoxifen, eventually become resistant to treatment. A new study finds this may be because of a mutation in the receptor present in the cancer cell to which tamoxifen binds.
(NewsUSA) - Michele Vela, 60, of Los Angeles was always diligent about her annual mammograms. Despite this, Michele was diagnosed with advanced (stage IV) breast cancer several years ago. After her diagnosis, Michele retired from her 33-year career as a postal worker and committed herself to fighting the disease. The experience gave her a new perspective, and she sought to make the most of every day: connecting with friends, playing golf and making time to take care of herself. "I was so frightened when I was first diagnosed with advanced breast cancer, but it is important to have hope," Vela said. Breast cancer is considered advanced when the cancer has spread to other parts of the body, for example, to tissue near the breast (known as "locally advanced") or to remote areas of the body, such as the brain, bones or liver (known as "metastatic"). Unlike some early-stage breast cancers, advanced breast cancer is not curable. Women with advanced breast cancer remain on treatment for the rest of their lives. In Michele's case, the cancer had spread to her bones. After testing, Michele learned that she had advanced hormone receptor-positive (HR+)/HER2 negative breast cancer. Advanced HR+/HER2 negative breast cancer is the most common form of the disease and is fueled by hormones such as estrogen and progesterone. With treatment, most recently including the common hormone therapy letrozole, Michele's cancer was kept under control for several years. Recently, Michele received the news she feared: the cancer had spread again, this time to her ribs. Michele worked closely with her doctor to learn about her options. Postmenopausal women with advanced HR+/HER2 negative breast cancer are often treated with hormone therapy, but resistance to hormone therapy can develop, causing tumors to grow and spread. After progressing on a treatment regimen including letrozole, Michele started a new treatment plan, which included Afinitor (everolimus tablets) and exemestane. Afinitor targets a specific pathway that may help extend the benefit of hormone therapy. The FDA approved Afinitor in 2012 for postmenopausal women with advanced HR+/HER2 negative breast cancer in combination with exemestane (a commonly used option) after failure of treatment with letrozole or anastrozole, offering another option for patients. "My diagnosis helped me realize how precious my life is and the people around me are," Vela said. "But the most important thing I've learned throughout my journey with the disease is that we are the beneficiaries of 21st-century medicine, and there are a lot of treatment options out there." A clinical trial found that adding Afinitor to the drug exemestane more than doubled the time women lived without tumor growth, to a median of 7.8 months compared to treatment with exemestane alone at a median of 3.2 months. In this study, the most common adverse reactions (incidence ? 30 percent) associated with Afinitor were mouth sores, infections, rash, tiredness, diarrhea and decreased appetite. Afinitor can cause serious side effects, including lung or breathing problems, infections and kidney failure, which can sometimes be fatal. If patients experience these side effects, they may need to stop taking Afinitor for a while or use a lower dose. Currently available data have not shown an increase in overall survival. Additional data will be available in the future. Afinitor® (everolimus) Important Safety Information Patients should not take Afinitor if they are allergic to Afinitor or to any of its ingredients. Before taking Afinitor, patients should tell their healthcare provider if they are allergic to sirolimus (Rapamune®) or temsirolimus (Torisel®). Afinitor can cause serious side effects, including lung or breathing problems, infections, and kidney failure, which can even be fatal. If patients experience these side effects, they may need to stop taking Afinitor for a while or use a lower dose. Patients should follow their healthcare provider's instructions. In some patients, lung or breathing problems may be severe and can even be fatal. Patients should tell their healthcare provider right away if they have any of these symptoms: new or worsening cough, shortness of breath, chest pain, difficulty breathing or wheezing. Afinitor may make patients more likely to develop an infection, such as pneumonia, or a bacterial, fungal or viral infection. Viral infections may include reactivation of hepatitis B in people who have had hepatitis B in the past. In some people, these infections may be severe and can even be fatal. Patients may need to be treated as soon as possible. Patients should tell their healthcare provider right away if they have a temperature of 100.5?F or above or chills, or do not feel well. Symptoms of hepatitis B or infection may include the following: fever, chills, skin rash, joint pain and inflammation, tiredness, loss of appetite, nausea, pale stools or dark urine, yellowing of the skin or pain in the upper right side of the stomach. Afinitor may cause kidney failure. In some people, this may be severe and can even be fatal. Patients should have tests to check their kidney function before and during their treatment with Afinitor. Common side effects include mouth ulcers. Afinitor can cause mouth ulcers and sores. Other common side effects include infections; feeling weak or tired; nausea and vomiting; skin problems; headache; weight loss; loss of appetite; cough; diarrhea; fever; swelling of the hands, arms, legs, feet, face or other parts of the body; joint pain, abnormal taste; stomach-area (abdomen) pain, nose bleeds, seizures, increased blood cholesterol and sugar levels, decreased blood phosphate levels, low red and white blood cells and the absence of menstrual periods (menstruation). Please see full Prescribing Information for Afinitor available at Afinitor.com. Rapamune® (sirolimus) and Torisel® (temsirolimus) are registered trademarks of Wyeth Pharmaceuticals Inc. For more information, talk to your doctor and visit www.Afinitor.com. AFB-1073449 10/2013
A new study shows young girls with higher body mass index, above the 85th percentile, tend to be starting puberty earlier. But, what does this mean for the health of your child?
BOCA RATON, Fla. (Ivanhoe Newswire) – Gynecomastia is an increasing problem affecting about 40 percent of men in this country. Enlarged male breasts can be caused by weight gain, estrogen, drugs, medications, and steroids. Now, one plastic surgeon has perfected a procedure that removes the breasts without leaving any scars.
How much does estrogen affect symptoms of mid-age spread? Studies conducted nationwide are closer to answers.
A bulging waistline, lack of energy and low libido are considered symptoms of men with low testosterone. Now, studies find estrogen may have to take part ownership for contributing to conditions men have come to accept as a normal part of aging. A combination of low estrogen not only low testosterone may be the the culprit of middle-aged men's woes.
How does having too much estrogen affect men?
Changes men experience as they age is not just the result of lowered testosterone levels, but lowered estrogen levels as well.
LONGWOOD, Fla. (Ivanhoe Newswire) – What if you could detect the beginnings of breast cancer years before it showed up on a mammogram? That’s what a new screening test is doing. The noninvasive test has the potential to cut breast cancer rates, just like pap smears have cut rates of cervical cancer.
CLEVELAND, Ohio (Ivanhoe Newswire) -- Two women, every fifteen minutes, will die of breast cancer. However, due to new drugs and new treatments, many, many more women will beat this disease. There is a new breakthrough that has women leaving the hospital in one day, surgery, radiation and all!
From stress to diabetes, even back surgery. Many things can cause Erectile Dysfunction and there are many ways to treat it. But men, if you don't want to pop a pill or go under the knife listen up! There are ways to fight E.D. naturally.
In the heads of millions of Americans, they sit silently and can burst without warning. Brain aneurysms rupture in about 30 thousand people every year, killing or disabling many.
(ARA) - Characterized as a generation who led the sexual revolution in the sixties, many baby boomer women are reluctant to talk with their partners or healthcare professionals about the conditions they're experiencing as a result of menopause, including vaginal atrophy (a-truh-fee). Why are they suffering in silence? And why has this discussion remained taboo even though it is shared by women everywhere? There is some basic information women should be aware of and an option that is available to help women relieve their postmenopausal vaginal symptoms.
(NAPSI)After a long, cold winter, most women look forward to the warm days of summer and enjoying some fun in the sun. But if youre among the approximately 75 percent of postmenopausal women who suffer from the symptoms of hot flashes,1 then the added heat of summertime may be too much of a good thing, leaving you desperate to find relief.
Think you're not at risk for osteoporosis because you're a male? Think again. Men make up 20 percent of all Americans suffering from the condition, according to medpagetoday.com.
(ARA) - As women enter their 40s and 50s, it's inevitable. Menopause will begin. And so will the hot flashes.
(NAPSI)—If youre a woman in your 40s or 50s beginning to experience symptoms associated with menopause, you may have some questions. Up to 40 percent of women suffer from the symptoms of hot flashes associated with menopause.1 The severity of hot flashes may vary from woman to woman. For some, hot flashes greatly impact daily activities while for others, theyre barely bothersome.1 So how do you determine the right course of action for managing your hot flashes? Dr. William Koltun, Medical Director for the Medical Center for Clinical Research offers up some facts to help you understand your changing body.