People without dementia may show signs of the disease decades before symptoms appear on brain scans if both of their parents have Alzheimer’s, according to a new study at the New York University School of Medicine.
The study split participants into four groups: those with a mother with Alzheimer’s, a father, both parents, and no family history of the disease. Results showed people with both parents who had Alzheimer’s had more abnormalities in brain volume, metabolism, and had five to ten percent increased brain plaques compared to the other three groups.
There might be genes that predispose people to develop brain Alzheimer’s pathology. “We do not yet know which genes, if any, are responsible for these early changes, and we hope that our study will be helpful to future investigations,” study author Lisa Mosconi, PhD, was quoted as saying.