Prenatal conditions linked to kidney disease in children?

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Prenatal risk factors are associated with the development of chronic kidney disease in children, according to study recently published in the Journal of the American Society of Nephrology.

Researchers studied 1994 patients with childhood chronic kidney disease (CKD) and 20,032 controls without the disease. The prevalence of CKD was 126.7 cases per 100,000 births. Infants with low birth weight were nearly three times more likely to develop childhood CKD than infants with normal birth weight. Infants were also at higher risk if their mothers developed diabetes during pregnancy or if their mothers were overweight or obese.

“Previous studies show that strict control of maternal diabetes significantly reduces the risk of congenital malformations in children,” Christine Hsu, MD, at the University of Washington, was quoted as saying. “We hope our work leads to future studies to investigate whether strict control of maternal diabetes and/or reducing maternal obesity/overweight reduces childhood CKD.”

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