Researchers from Wales have identified a key gene in breast cancer cells and found when they suppressed the gene, cancer growth reduced by 80 percent.
The gene, called Bcl3, was identified by researchers at Cardiff University. After identifying the gene, researchers used a computer model to find a drug candidate that could inhibit Bcl3. They tested the compound on mice, and found the drug stopped the mice’s tumors from spreading. Researchers are now attempting to get the compound into human clinical trials.
“Despite great improvements in therapy of early stage breast cancer, the current therapeutic options for patients with late stage metastatic disease are limited,” researcher Dr. Richard Clarkson was quoted as saying. "There is therefore a clear unmet clinical need to identify new drugs to reverse or at least to slow down disease progression.”