Chronic inflammation in benign prostate tissue is associated with aggressive prostate cancer, according to a study published in Cancer Epidemiology, Biomarkers, & Prevention, a journal of the American Association for Cancer Research.
For the study, researchers examined benign tissue from biopsies of 191 men with prostate cancer and 209 men without cancer. They found that 86.2 percent of the prostate cancer had at least one tissue sample with signs of inflammation, compared to 78.2 percent of men without cancer. Those whose benign prostate tissue had chronic inflammation had 1.78 times higher odds of having prostate cancer, and 2.24 times higher odds of having an aggressive disease, compared with those whose benign prostate tissue had no inflammation.
“Our team is next studying the type of inflammatory cells that may be influencing the risk of aggressive prostate cancer,” Elizabeth A. Platz, Sc.D., MPH, at Johns Hopkins Bloomberg School of Public Health in Baltimore, was quoted as saying. “This study is a stellar example of multidisciplinary research involving epidemiologists, pathologists, immunologists, urologists, and biostatisticians.”